CHAPTER 10 / 生命医学
複数の証拠段階理化学研究所・細胞系譜・STAP問題
RIKEN, Cell Lineages and the STAP Controversy
理研のscRNA-seq系譜推定を条件付きの解析法として扱い、STAP撤回・未再現と明確に区別する。
RIKEN lineage inference is treated as a conditional analytical method, distinct from retracted STAP claims.
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JA 日本語
EN English
RIKEN reported lineage reconstruction using somatic variants inferred from normal-tissue scRNA-seq, tested in simulations and human placenta data 1. Performance depends on mutation count, cell number, allelic dropout, and RNA-specific missingness; it is not validation for every cell system or CAP response. October 2026 reports concern an amino-acid-limited primitive enzyme model catalysing an ATP-generation reaction 2 and membrane-dependent DOCK11/Cdc42 positive feedback 3, not input-free power or plasma therapy. The STAP papers were retracted and unreplicated; new cell science does not reinstate them.